Guberman-Pfeffer, M.; Greco, J. A.; Samankumara, L.; Zeller, M.; Gascón, J.; Birge, R.R.; Brückner, C. ‘Bacteriochlorins with a Twist: Discovery of a Unique Mechanism to Red-shift the Optical Spectra of Bacteriochlorins’ J. Am. Chem. Soc. 2017, 139 (1), 548–560. DOI: 10.1021/jacs.6b12419
A collaborative effort within the chemistry department brought experiment and theory together to explain the unique optical properties of a class of analogues to the bacterial photosynthetic pigments. We hope this work will point the way in the design of mechanochromic dyes, i.e., dyes that change their color when exposed to mechanical stress.
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Spundana Malla, Karteek Kadimisetty, You-Jun Fu, Dharamainder Choudhary,
John B. Schenkman & James F. Rusling
Methyl-Cytosine-Driven Structural Changes Enhance Adduction Kinetics of an Exon 7 fragment of the p53 Gene. Sci. Rep. 7, 40890; doi: 10.1038/srep40890 (2017).
In a collaborative effort with UConn Health (Profs. Schenkman and Choudhary), Spundana Malla, Karteek Kadimisetty, Dr. Fu and Prof. Rusling reported a new LC-MS method to investigate the kinetics of gene damage. The paper describes the use of the method to investigate metabolite-related damage to p53 tumor suppressor gene, which is damaged in 50% of all cancers. Results show that a specific cytosine-guanine site (codon 248) on the p53 gene reacts 3-fold faster when the cytosine is methylated.
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Is laughing gas a bad thing? In a WAMC Radio “Academic Minute” segment, Dr. Nicholas Leadbeater explores this silly question.
Listen here >>>
Artwork based on research between Dr. Flavio Maran and Dr. José A. Gascón has been featured in the covers of Chemical Science. The image depicts “a magnetic look into the protecting layer of Au25 clusters.”
View cover here>>>
A publication titled, “White-emitting protein nanoparticles for cell-entry and pH sensing” has been accepted as a VIP paper in Advanced Functional Materials, 2016, DOI: 10.1002/adfm.201603874. Bobbi S. Stromer and Challa V. Kumar are the authors of this paper.
Cover art pictured was submitted by Caterina Riccardi (Kumar Group).
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Congratulations to Graduate Student Islam Mosa for winning the People’s Choice Award in the International Universitas 21 (U21) Three Minute Thesis (3MT) Competition. This is the first international award for UConn in the U21 3MT competition. Islam received his award from Dr. Kent Holsinger, Dean of the Graduate School. Also, President Herbst has invited Islam to attend the Board of Trustees meeting to congratulate him for his achievement. Islam is now the winner of the Department’s and UConn’s 3MT competitions, as well as the International U21 3MT People’s Choice Award.
The 2016 competition experienced the highest number of participating students – over 1000 students presented in local heats across the network – and the People’s Choice Award saw its highest total number of online votes in the competition history; Islam received the highest number of votes among all participants.
Islam would like to thank his advisor, Dr. Jim Rusling, for the support and constructive feedback, Dr. Challa Kumar for instructing the technical communication course, and to the entire Chemistry Department for voting and supporting him!
Full U21 Story >>> | Video >>>
The University of Connecticut (UConn) is entering a transformational period of growth supported by the $1.7B Next Generation Connecticut (http://nextgenct.uconn.edu/) and the $1B Bioscience Connecticut (http://biosciencect.uchc.edu/) investments and a bold new Academic Vision (http://academicvision.uconn.edu). We are pleased to continue these investments by inviting applications are invited for a tenure-track position in the Chemistry Department.
The Chemistry Department at the University of Connecticut (UConn) seeks applications for a full time tenure-track position to begin in August 2017. All areas of organic, bioorganic, or biological chemistry will be considered, with preference given to candidates whose research contributes to the above initiatives and complements that of current faculty. Continue reading
Dr. Challa Kumar and Graduate Student Melissa Limbacher are the recipients of an Accelerate UConn Fall 2016 Grant for their project entitled, “GlowDots.”
Kumar and Limbacher will participate in the Fall cohort of Accelerate UConn, the University’s National Science Foundation I-Corps site. All winning teams receive special training and a $3,000 seed grant to help understand whether and how their technology might create customer value.
See all Accelerate winners here >>>