The preliminary schedule has been published below.

Events are currently scheduled to be held at the Sheraton Philadelphia City Center Hotel. (Room number to be available soon.)
The hotel is within walking distance from the Convention Center.

17th & Race Street, Philadelphia, PA 19103
(213) 448-2000

Monday, 18 August 2008
830 - 835	Opening Remarks
835 - 910	Nicholas E. Leadbeater: Microwave heating: A versatile tool for clean organic synthesis and biofuel production
	Microwave heating offers a versatile platform for preparative organic chemistry. It is possible to perform reactions in minutes instead of hours and, in many cases, obtain high yields of desired products. As the field develops, new avenues for microwave-promoted chemistry are developing. In this presentation we will show how we have incorporated the concepts of green chemistry into methodologies using microwave heating in our laboratory; taking advantage of the short reaction times and improved efficiencies. After a discussion of the use of water as a solvent for a number of carbon-carbon bond forming reactions, particular emphasis will be placed on approached to scale-up reactions using microwave heating. Applications to biofuel manufacture will be used as examples. The use of gaseous reagents in conjunction with microwave heating as well as development of in-situ reaction monitoring techniques will also be outlined.
910 - 945	Walter Leitner: Catalysis as key technology and fundamental science for green chemistry
	Catalytic molecular transformations are of paramount importance to secure a sustainable chemical supply chain. They address the continuing need to utilize energy and resources efficiently in waste-minimized chemical processes. The rapidly increasing interest in biomass derived feedstocks imposes also fundamentally new challenges on the development of catalysts and catalytic processes. With this background, the present talk will highlight three areas of catalysis science: - New catalysts and catalytically active materials - Design of synthetic pathways and transformations - New reaction engineering principles on basis of alternative reaction media
	The direct relation of these fundamental scientific challenges to the Green Chemistry principles will be discussed and illustrated with topical examples from current research.
945 - 1020	Terrence J. Collins: Design, performance and mechanistic chemistry of Fe-TAML activators; Reducing and eliminating hazardous substances
	Iron-TAML (Tetra-Amido-Macrocyclic-Ligand) activators are small molecule mimics of peroxidase enzymes. The key to their success has been a iterative design protocol carried out for 15 years to the prototype, and thereafter for further advancement, focused primarily on obtaining strongly electron-donating ligand systems where derivative complexes resist both hydrolytic and oxidative degradation. Ferric-TAML complexes with peroxides produce extremely reactive intermediates, probably several separately or jointly depending on the conditions, one of which is likely to be an iron(V)-oxo complex that has been trapped at low temperature. Fe-TAML catalysis is distinguished by low catalyst requirements (nM to low microM), efficacy under ambient conditions over a broad pH range (especially neutral to highly basic), rapidity, high efficiencies and turnover numbers, and flexibility for both selective and non-selective processes; the latter can be described as “fire-in-water”. Fe-TAML/hydrogen peroxide's use to purify water of numerous recalcitrant pollutants and hardy pathogens will be reviewed.
1020 - 1035	Intermission - Coffee Break
1035 - 1110	Joan F. Brennecke: Green solvents: The good, the bad and the ugly
	Solvents are a major source of atmospheric emissions, which contribute to poor air quality, climate change and decreased worker health and safety, by the chemical and related industries in the U.S. Efforts to replace traditional volatile organic solvents include solventless processes, use of water, lower volatility organic solvents, and supercritical carbon dioxide, as well as development and implementation of extremely low volatility ionic liquids. We will discuss the pros and cons of these alternatives, placing special emphasis on the rapidly developing field of ionic liquids. We will talk about their many potential uses, as well as the wide variety of toxicity one can achieve with various anions, cations and functional groups.
1110 - 1155	Mary M. Kirchhoff: Green chemistry: Principles, practice, and economics
	Green chemistry, the design of chemical products and processes that reduce or eliminate the use and generation of hazardous substances, is the most fundamental approach to pollution prevention. Green chemistry addresses the need to produce the goods and services that society depends on in a more environmentally benign manner. The focus of green chemistry is on pollution prevention, rather than treatment and disposal of hazardous waste after it has been generated. The implementation of green chemistry technologies has eliminated waste, improved safety, and saved industry money. This presentation will introduce the principles of green chemistry, provide academic and industrial examples of greener technologies, and highlight the economic benefits of adopting environmentally friendly processes.
1155 - 1200	Concluding Remarks
1200 - 130	Break for Lunch
130 - 135	Industrial Session Opening Remarks
135 - 210	Lisa B. Cleckner : Successful academic-industry collaboration in green technologies through the federation model
	The Syracuse CoE Office for Industry Collaboration (Syracuse CoE OIC), a not-for-profit 501(c)(3) corporation, has a vision to transform Central Upstate New York into a nationally and internationally known center for environmental and energy systems through close interaction with the Syracuse Center of Excellence, a federation of more than 200 firms and institutions focusing on Clean and Renewable Energy, Indoor Environmental Quality, and Water Resources for the built and urban environments. This transformation is being accomplished by fostering collaborative projects between top academic institutions and industry, by providing a mechanism for funding research and technological innovation and by facilitating the identification, development, application demonstration, and commercialization of products and services. Other key components of this successful collaborative model include the ability to financially assist companies in Central Upstate New York in order to host college level internships, in partnership with top academic institutions within the Syracuse CoE federation; creating a fundamental and necessary means of “knowledge transfer;” and increasing public understanding of key issues in the federation's three focus areas, through education, communications, and outreach programs. Finally, partnerships with local and state economic entities—along with other nationally known funding agencies—are essential for the entire model to succeed. Successful execution of the collaborative federation model is evidenced by knowledge creation; the number of new products and services in the federation's focus areas developed and marketed; and the resulting wealth creation, and ultimately, job creation.
210 - 245	Joseph D. Armstrong III: Green chemistry through innovation at Merck: The synthesis of Januvia
	Different approaches utilizing Green Chemistry to drive innovation at Merck will be presented. The specific case study for the synthesis of Januvia will be detailed. An environmentally responsible new route for the manufacture of Januvia has been achieved through scientific innovation. Januvia is a new treatment for type II diabetes which is currently being evaluated in late-stage clinical trials. A first generation process, which used existing methodology to synthesize Januvia , was used to prepare over 100 kg of material and, with modifications, would have been a viable manufacturing process. However, in order to develop a highly efficient process for the preparation of Januvia, Merck researchers discovered a completely unprecedented transformation, the asymmetric catalytic hydrogenation of unprotected enamines. This new method provides a general solution to the synthesis of beta-amino acids; a class of molecules well known for their interesting biological properties. Merck scientists and engineers have applied this new method in a completely novel way, using it in the final step of synthesis, which maximizes the efficiency of the new route. This strategy is broadly applicable to other pharmaceutical targets and has been applied to the synthesis of several exploratory Merck drug candidates. Implementation of the new route on manufacturing scale has led to over an 80% reduction in the amount of waste produced and elimination of aqueous waste streams. The technology discovered, developed and implemented by Merck for the manufacture of Januvia is an excellent example of scientific innovation resulting in benefits to the environment.
245 - 320	David Constable: Lessons learned through measuring green chemistry performance of development routes at GSK
	One of the goals of GlaxoSmithKline's Sustainable Processing Team is to promote the design and development of more efficient chemistries and processes. By efficient we mean processes that use less mass and energy per kg of active drug substance, create less waste, use inherently less hazardous reaction conditions and chemicals, and in general move GSK towards more sustainable business practices. In order to design more sustainable chemistries and synthetic routes, GSK systematically and continuously measures and monitors green chemistry performance throughout the development cycle. To do this, GSK has selected key green chemistry metrics and has designed tools to facilitate chemical, chemistry and process assessment. The tools include solvent and material selection guides, a Green Chemistry and technology guide, a chemical legislation guide, and others that have been previously reported. A set of agreed targets with benchmarks for each clinical development phase are provided and these are accompanied by guidance and interpretation that is communicated directly to the development scientists responsible for optimizing GSK chemistries and processes. Life cycle environmental impacts are also included as part of our continuing assessment of synthetic routes under development through our tool FLASC (Fast Life cycle Assessment of Synthetic Chemistry). The inclusion of life cycle metrics is especially important for supply chain management in light of the growing trend to outsource manufacturing within the pharmaceutical industry. This presentation intends to share GlaxoSmithKline's experiences with systematically measuring, comparing and evaluating synthetic chemistry routes using key ‘green chemistry' metrics. It also explores the opportunities and challenges encountered in implementing green chemistry concepts within a research and development framework.
320 - 335	Intermission - Coffee Break
335 - 410	Victor A. Atiemo-Obeng: Practice of sustainable chemistry at Dow: Historical and future perspectives
	Sustainability at The Dow Chemical Company received a lot of attention with the introduction in 2006 of the company's 2015 Sustainability Goals. The focus on sustainability at Dow however dates back much earlier. In this presentation specific examples encompassing both internal and external initiatives, programs and investments will be described and used to highlight Dow's long history in the practice of sustainability in the biggest chemical company in North America. How these efforts inform the current and future perspectives on Green or Sustainable Chemistry at Dow will discussed.
410 - 455	Berkeley W. Cue Jr.: Greening the pharmaceutical industry: Accomplishments and opportunities
	The pharmaceutical industry has been at the forefront in adopting green chemistry and engineering as an important approach for the design of its active pharmaceutical ingredient (API) manufacturing processes, evidenced by winning the US EPA Presidential Green Chemistry challenge several times over its twelve year history. In 2005 several companies came together with the ACS Green Chemistry Institute to form a Pharmaceutical Roundtable, which, today, comprises eight member companies. These companies meet on a regular basis to discuss pre competitive and non competitive issues relating to green chemistry, and have made notable progress in achieving their common goals. These goals and accomplishments around greener chemical reactions, benchmarking environmental footprint reductions, legislative action, education and globalization will be discussed along with opportunities to expand membership, and take on some of the most challenging R&D problems facing this industry around environmental stewardship. The talk also will explore the challenging business environment in which the industry finds itself and its possible impact on these R&D efforts.
455 - 500	Concluding Remarks
500 - 700	Poster Session / Reception / Exposition