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James D. Stuart
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(b. 1941)
Visiting Fellow, Yale University, 1983
Visiting Lecturer, University of Georgia, 1976
Instructor, Lafayette College, 1967-1969
Ph.D., Lehigh University, 1969
B.S., Lafayette College, 1963
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My primary
research interests involve the use of the modern forms
of gas and liquid chromatography to obtain interesting
and worthwhile analytical separations. The research
is both fundamental and applied in nature. It employs,
either high performance liquid chromatography (HPLC),
high performance liquid chromatography/mass spectrometry
(LC/MS), capillary column gas chromatography (GC) and/as
chromatography/mass spectrometry (GC/MS) to analyze
for organic compounds in a variety of matrices. Computer-based
expert chromatographic systems for method development
in GC and reversed-phase LC separations are used. For
the key sample preparation step, such methods as solid-phase
extraction (SPE) and micro solid-phase extraction (SPME)
are used. On the applied side, research has involved
developing the separation of organic chemicals, up to
the size of proteins, in such matrices as body fluids,
environmental samples, foods and flavors, various petroleum
products and in pharmaceutical preparations. Recent
work has been directed to the analysis of various amino
acids and methyl benzoic acids, phthalate and adipate
esters, various aromatic and oxygenate compounds in
petroleum fuels. In collaboration with a groundwater
hydrogeologist, interdisciplinary research has focused
on developing meaningful field methods for evaluating
the effect of leaking underground gasoline tanks (gasoline
stations). A rapid, static headspace method depends
of Henry's Law to describe the equilibrium of analyte(s)
between the liquid (or solid) and headspace phase is
used. Recent interest has centered on the analysis of
the oxygenate methyl-t-butyl-ether (MTBE) in unleaded
gasoline and groundwater as MTBE has been shown to be
early indicator of subsurface gasoline contamination.
Reversed-phase HPLC is used in the analysis of a family
of methyl-substituted benzoic acids in attempt to show
that they represent a stable and reliable indicator
of sub-surface, intrinsic, natural bioremediation of
the gasoline occurring in the subsurface. contaminated
sites.
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