A recent paper from the Pinkhassik Group was featured on the cover of ACS Applied Materials & Interfaces (ACS Appl. Mater. Interfaces, 2016, 8 (30), pp 19755–19763). The study described the creation of size- and charge-selective nanoprobes for surface-enhanced raman scattering (SERS). The cover image illustrates the application of selective SERS nanoprobes in the trace analysis of small molecules in blood plasma without the need for sample pretreatment. The selectivity is achieved by controlling the size of nano pores or the charge of the shells of nanocapsules. Dr. Sergey Shmakov (UConn) and Ying Jia (Saint Louis University) contributed to this work.