Western Connecticut is known for rolling hills, rich history, and industry, such as hat making. Once called the “Hat City of the World,”Danbury thrived. Anyone familiar with Lewis Carroll’s Mad Hatter may also be aware of the dangers of hat making, due to the industry’s use of the potent toxin mercury. Starting in the late 1700s, Danbury hat factories were a point source of pollution, dumping large quantities of mercury into the nearby Still River.
Fashions change, the use of mercury in hat making was outlawed in 1940, and now all that remains of the once-thriving hatting industry in Danbury is its history – or is it?
A group of researchers from UConn and Wesleyan University spent four years studying a stretch of the Still River, and found that the industrial waste of a century ago is still very much present in 2020.
For well over 100 years, only two pigments have been identified in avian eggshells: rusty-brown protoporphyrin (e.g., brown chicken eggs) and blue-green biliverdin (e.g., turquois eggs of robins). However, tinamou (chicken-like forest dwellers of South America) eggshells display unusually colored eggshells, suggesting the presence of other pigments. The Brückner Group, in collaboration with the ornithologists and eggshell and bird color experts Daniel Hanley (Long Island University) and Richard Prum (Yale University), investigated this. Through extraction, derivatization, spectroscopy, chromatography, and mass spectrometry, they identified two novel eggshell pigments: yellow–brown bilirubin and red–orange uroerythrin from the guacamole-green and purplish-brown eggshells of two tinamous species. Both pigments are known porphyrin catabolites and were found in the eggshells in conjunction with biliverdin. A colour mixing model using the new pigments and biliverdin reproduced the respective eggshell colours. These discoveries expand our understanding of how eggshell colour diversity is achieved. The ability of these pigments to photo-degrade may have an adaptive value for the tinamous – this is the subject of follow-up studies for the ornithologists.
Hamchand, R.; Hanley, D.; Prum, R.O.; Brückner, C. ‘Expanding the Eggshell Colour Gamut: Uroerythrin and Bilirubin from Tinamou (Tinamidae) Eggshells’ Sci. Rep.2020, 10, 11264.
University of Connecticut professor of molecular and cell biology James Cole* is working on identifying new therapeutics for COVID-19.
Through a collaboration with Atomwise, a California-based company which uses artificial intelligence to advance small molecule drug discovery, Cole is one of the 15 researchers looking at different coronavirus protein targets for COVID-19 treatment.
Cole is focusing on the NSP15/EndoU ribonuclease enzyme the COVID-19 virus needs to replicate as well as degrade viral RNA to hide it from host cell defenses. Cole is looking for a molecule that can inhibit the enzyme and thus inhibit replication of coronaviruses.
“The virus and the host carry out this war,” Cole says. “The virus has to evade the host’s innate immunity response while the host is trying to stop the virus from replicating.”
By inhibiting this enzyme, the body’s innate immune system would prevent the virus from replicating. Continue reading →
UConn associate professor of pharmaceutics Xiuling Lu, along with professor of chemistry Rajeswari M. Kasi, was part of a team that recently published a paper inNature Cell Biologyfinding a commonly used chemotherapy drug may be repurposed as a treatment for resurgent or chemotherapy-resistant leukemia.
One of the largest problems with cancer treatment is the development of resistance to anticancer therapies. Few FDA-approved products directly target leukemia stem cells, which cause treatment-resistant relapses. The only known method to combat their presence is stem cell transplantation.
Leukemia presents unique treatment challenges due to the nature of this form of cancer. The disease affects bone marrow, which produces blood cells. Leukemia is a cancer of the early blood-forming cells, or stem cells. Most often, leukemia is a cancer of the white blood cells. The first step of treatment is to use chemotherapy to kill the cancerous white blood cells, but if the leukemia stem cells in the bone marrow persist, the cancer may relapse in a therapy-resistant form. Continue reading →
A molecular engineering principle in which repeat units of fairly rigid fused bicyclic structure and alkenes, separated by freely rotating single bonds, is proposed by Gregory A. Sotzing, Yang Cao, and published as a cover highlight of the May 26th Issue of Advanced Materials in article number 2000499, led by Dr. Chao Wu, a PDF at EIRC, and Ajinkya Deshmukh, a Polymer Program Ph.D. student for energy storage at elevated temperature.
The piston‐like crankshaft structure endows the system with a large bandgap of ≈5eV and flexibility, while being temperature‐invariantly stable. The piston/pendant allows engineering for temperature‐invariant dipolar polarization for energy storage. As part of a UConn lead MURI program, the design strategy uncovered in this work reveals a hitherto unexplored space for the design of scalable and efficient polymer dielectrics for electrical power and electronic systems under concurrent harsh electrical and thermal conditions.
LambdaVision was awarded five million dollars from NASA to continue their work on the International Space Station (ISS) for an artificial retina that could help patients regain their sight. The award will fund flights to the ISS for the next three years to manufacture and improve the artificial retina technology previously developed by LambdaVision. The layer-by-layer process of producing the protein-based artificial retina requires less materials in a microgravity environment, reducing its cost and production time. In the future, LambdaVision hopes to begin clinical trials for their artificial retina technology.
LambdaVision was founded as part of the UConn Technology Incubator Program (TIP) and is spearheaded by Nicole Wagner (CEO) and Jordan Greco (CSO). Wagner and Greco are alumni of Dr. Robert Birge’s research group and currently serve as Assistant Research Professors in UConn’s Chemistry Department.
Congratulations to Ph.D. candidate Matthew Howell, the recent recipient of a prestigious NSF Graduate Research Fellowship. This fellowship will begin in Fall 2020 and continue through Spring 2023. Given the growing crisis of antibiotic resistant bacteria, Matthew—in collaboration with advisor Dr. Alfredo Angeles—is interested in examining the relationships between peptides, metal ions, and antibiotics. Together, they are searching for combinations that demonstrate synergistic killing of these bacteria.
Researchers from the University of Connecticut’s Sotzing Research Group are studying conductive and dielectric polymers for a number of applications, from color-changing fabric to medical applications of chemicals in cannabis to high-speed projectile launchers for the military.
The group is led by chemistry professor Gregory Sotzing. The group’s wide-ranging base of research is due to the number of applications for the polymers they study.
Sotzing explained that studying polymers really just means making new kinds of materials.
“We’re pretty much the people who make new materials, new compositions of matter. Then the engineers will take and test out these new things and see how well they work inside of certain kinds of applications,” Sotzing said.
The University of Connecticut has been recognized among the top producers of Fulbright U.S. Scholars from research institutions for the second time in the past four years.
The University has six Fulbright Scholars on its faculty who are teaching and performing research around the world in the 2019-20 academic year, according to the U.S. Department of State’s Bureau of Educational and Cultural Affairs, which was featured in The Chronicle of Higher Education on Monday.
The Fulbright Program is the government’s flagship international educational exchange program. Scholars are selected for their academic merit and leadership potential, with the opportunity to exchange ideas and contribute to finding solutions to shared international concerns.
The Fulbright U.S. Scholar Program operates in more than 125 countries. The following UConn faculty are pursuing Fulbright projects abroad:
Associate Professor of SociologyMatthew Hughey, will conduct research on “White Racial Identity, Organizational Homogeneity, and Stratification of Benefits in Surrey” at the University of Surrey in Guildford, England.
Professor of ChemistryChalla Kumar, will conduct research on “BioNanoMaterials for Additive Manufacturing (3D Printing) of Biobatteries” at the University of Wollongong in Wollongong, Australia.
Professor of Painting in the School of Fine ArtsKathryn Myers, will lecture in “Professional Practices for Studio Artists” at Banaras Hindu University in Varanasi, India.
Associate Professor of Civil and Environmental EngineeringMalaquias Pena-Mendez, will conduct research on “Ensemble Predictions for Urban Areas” at the Federal University of Alagoas in Maceio, Brazil.
Associate Professor of EnglishBhakti Shringarpure, will conduct research on “The World Novel from Africa: Mapping Migrant Forms in East African Literature” at the University of Nairobi in Nairobi, Kenya.
Associate Professor of Marine SciencesMichael Whitney, will conduct research on “The Icelandic River Influences on Coastal and Open Ocean Waters” at the University of Iceland in Reykjavik, Iceland.
UConn’s Office of National Scholarships & Fellowships collaborated with the Office of Global Affairs and the Asian and Asian American Studies Institute to host Fulbright Week at UConn for the first time in 2019.
This year, Fulbright Week at UConn events will be held April 13-17, 2020. Together with a representative from the Institute of International Education, which administers the Fulbright programs, information sessions for faculty, graduate, and undergraduate students will be offered, along with one-on-one faculty advising sessions with the IIE representative, a live session with a current Fulbright student abroad, and a reception for current and former UConn Fulbright Scholars.
The Fulbright Program is funded through an annual appropriation by the United States Congress to the Department of State. Participating governments and host institutions, corporations, and foundations in foreign countries and the U.S. also provide direct and indirect support.
Undergraduate student Eric Mohan ’20 (CLAS), recipient of an Office of Undergraduate Research award, shares his experience conducting research abroad.
“I am the recipient of the 2019 Office of Undergraduate Research (OUR) award, and I had the privilege of spending last summer in the laboratory of Professor Dominic Campopiano, in the School of Chemistry at the prestigious University of Edinburgh in the United Kingdom. This was an amazing experience to work with a renowned professor helping solve an unmet and urgent medical need related to the resurgence of antibiotic resistance. My project focused on the inhibition of an important enzyme found in many infectious bacteria, such as those causing Tuberculosis. I was tasked with synthesizing, modeling, and characterizing the pathway by which a compound, ERG240, blocked the branch chain amino acid aminotransferase enzyme. I used optically active coupled reactions in this work. We then co-crystallized the inhibitor with the enzyme and employed x-ray crystallography to fully understand the mechanism of the enzyme. My research was presented as a poster at the Fall Frontiers program 2019 at UConn, Storrs. Continue reading →
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