- Postdoctoral Fellow, MIT, 1984
- Ph.D. Wayne State University
- B.S. University of Calcutta, India
Mechanism of action of the antitumor drug mitomycin C. Investigation of the mechanism of mutagenesis and repair of the DNA damages derived from γ radiation, oxidation, and environmental pollutants such as nitrated pyrenes that are suspected to pose threats to human health. A primary goal of this work is to define the relationship between the structure and three-dimensional effects of a solitary lesion in DNA and the mutagenicity, toxicity, and DNA repair that it may induce. We address various mechanistic details as to how the differences in organisms, DNA polymerases, and repair proteins may influence the biological outcome of a lesion.